Published in 1982 Hoyle calculated that the chance of obtaining the required set of enzymes for even the simplest living cell was one in 10^40,000 (10 with 40,000 zeros after it). As comparison, the number of atoms calculated to be in the universe is 10^80, he thus argued that life could not have originated on earth by natural processes, stating;
“The notion that not only the biopolymer but the operating program of a living cell could be arrived at by chance in a primordial organic soup here on the Earth is evidently nonsense of a high order.”
He also made this statement in the same year;
“If one proceeds directly and straightforwardly in this matter, without being deflected by a fear of incurring the wrath of scientific opinion, one arrives at the conclusion that biomaterials with their amazing measure or order must be the outcome of intelligent design. No other possibility I have been able to think of…”
—Fred Hoyle, Royal Institution’s Omni Lecture, 1982
Whats even more remarkable is that hoyle was an atheist and evolutionist. Rather than coming to the conclusion of a superconscious Creator transcendent of the physical universe, he instead seems to have opted for belief in an alien creator and transference of biological elements from comets.
Of course attributing the design of life to aliens does not solve the question of origins, it just pushes it back further, as how did the aliens originate their DNA if it is mathematically absurd it could have formed randomly and unconsciously.
The rational existential conclusion is that there is a consciousness transcendent of the finite material universe who imputed and designed it, and is not subject to its laws and limits of space and time.
Only such a creator is eternal, independent of the universe and so not subject to requiring creation Himself.